At some point, you end up with one little piece of your system, as a whole, where you end up spending all your time. If you write that just as a sort of simple-minded Python loop, at some point you will see that that is the bottleneck in your system. It is usually much more effective to take that one piece and replace that one function or module with a little bit of code you wrote in C or C++ rather than rewriting your entire system in a faster language, because for most of what you're doing, the speed of the language is irrelevant.
import yourmodule
pip install cython